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Evaluation of the phytochemical and biological properties of Prismatomeris tetrandra (Roxb.) K. Schum
Nor Hayati Abdullah , Fadzureena Jamaludin, Chee Beng Jin, Vimala Subramaniam, Saiful Azmi Johari, Ong Boo Kean

Abstract
The methanol extracts of the roots, stems, and leaves of Prismatomeris tetrandra were evaluated for their bioactivity on antiinflammatory, antioxidant, antimicrobial, and antidiabetic. The result showed that the stem showed the highest activity on lipoxygenase at 61.04 and antioxidant (DPPH Radical Scavenging Assay >100.0 + 0.0; Xanthine/xanthine oxidase Superoxide Scavenging System 74.6 + 2.6). The roots however performed the highest activity on insulinotropic assay at 1.8081 mg/ml) and antimicrobe against the growth of Vancomycin-Resistant S. aureus, Vancomycin intermediate S. aureus, and Staphylococcus aureus strains and able to kill the microbes. The MIC and MBC ranging between 0.625 to 2.50 mg/ml for all microbes. From the phytochemical screening and TLC profile, it can be concluded that different parts of this plant comprising of different chemical constituents. This might explain the differences in the bioactivity of different parts. The findings from this study can be used for further study in searching new active compound which can be used as a lead compound or this plant may be developed into a potential herbal product.

Keywords: Prismatomeris tetrandra, anti-inflammatory, antidiabetic, antioxidant, antimicrobe, phytochemical screening